Virginia Tech (10) - Preferred Winners For Week 1 Matchups
| Thursday, September 2 | |||||||
| TIME (ET) | VISITOR | HOME | TV | ||||
| 6:30 PM |  | Presbyterian | @ |  |
| ||
| 7:00 PM | | Hampton | @ |  |
| ||
| 7:30 PM |  |
| @ |  | Ohio State (5) | BTN | |
| 8:30 PM |  | Pittsburgh (15) | @ |  |
| VERSUS | |
| TBA | | Florida A&M | @ |  |
| ||
| Saturday, September 4 | |||||||
| TIME (ET) | VISITOR | HOME | TV | ||||
| 12:00 PM |  |
| @ |  | Florida (3) | ||
| 12:00 PM | | Samford | @ |  |
| ESPNU | |
| 12:00 PM | |
| @ |  | Penn State (9) | BTN | |
| 12:05 PM | |
| @ |  | Iowa (7) | BTN | |
| 1:00 PM | | South Carolina State | @ |  |
| ||
| 1:00 PM | | Weber State | @ |  |
| ||
| 3:30 PM |  |
| @ |  | Oregon (11) | ||
| 3:30 PM |  | North Texas (117) | @ |  |
| ||
| 3:30 PM |  | Texas (2) | @ |  |
| ESPN | |
| 6:00 PM | | Richmond | @ |  |
| ||
| 6:00 PM | | Western Carolina | @ |  |
| ||
| 7:00 PM | | Elon | @ |  |
| ||
| 7:00 PM |  |
| @ |  | Brigham Young (12) | CBSC | |
| 7:00 PM |  |
| @ |  | Nebraska (14) | ||
| 7:45 PM |  |
| * |  | TCU (6) | ESPN | |
| 8:00 PM |  | LSU (17) | * |  |
| ABC | |
| 10:00 PM |  | Cincinnati (8) | @ |  |
| ESPN2 | |
| 11:00 PM |  | Wisconsin (16) | @ |  |
| VERSUS | |
| TBA | |
| @ |  | Mississippi (20) | ||
| TBA |  |
| @ |  | Alabama (1) | ||
| Sunday, September 5 | |||||||
| TIME (ET) | VISITOR | HOME | TV | ||||
| 2:00 PM |  | Tulsa (90) | @ |  |
| ESPN2 | |
| Monday, September 6 | |||||||
| TIME (ET) | VISITOR | HOME | TV | ||||
| 4:00 PM |  | Navy (28) | * |  |
| ESPN | |
| 8:00 PM |  | Boise State (4) | * | |
| ESPN | |
| * - Game played at a neutral location. |
